Click Multivalent Heterogeneous Neoglycoconjugates - Modular Synthesis and Evaluation of Their Binding Affinities
The efficient synthesis of structurally diverse, multivalent, heterogeneous neoglycoconjugates by means of a series of different click‐based strategies is described. The methodology is highly efficient and versatile allowing for easy access to a series of mannose (α‐Man)‐containing glycoconjugates d...
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Published in | European Journal of Organic Chemistry Vol. 2009; no. 15; pp. 2454 - 2473 |
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Main Authors | , , , , , |
Format | Book Review Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.05.2009
WILEY‐VCH Verlag Wiley Wiley-VCH |
Subjects | |
Online Access | Get full text |
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Summary: | The efficient synthesis of structurally diverse, multivalent, heterogeneous neoglycoconjugates by means of a series of different click‐based strategies is described. The methodology is highly efficient and versatile allowing for easy access to a series of mannose (α‐Man)‐containing glycoconjugates differing in their valency, nature of the scaffold, nature of the constitutive sugars and length of the linker. The influence of those structural parameters on the binding affinities of these glycomimics toward Concanavalin A (Con A) was evaluated.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Multivalent neoglycoconjugates containing two different sugars were synthesized by a modular strategy based in the CuI‐catalyzed azide‐alkyne cycloaddition reaction and their binding affinities toward Concanavalin A were evaluated. |
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Bibliography: | Dedicated to Professor Hans Helmut Baer ArticleID:EJOC200801169 ark:/67375/WNG-MHGVLM3J-G Dirección General de Investigación Científica y Técnica (DGICYT) - No. CTQ2005-02219 istex:469AA9867EDADE5C0FFA4D418243F58FAFF9F3D6 |
ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.200801169 |