Radiosynthesis of 11-[18F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer
Changes in the magnitude of the mitochondrial membrane potential occur in a range of important pathologies. To assess changes in membrane potential in patients, we set out to develop an improved mitochondria‐targeted positron emission tomography probe comprising a lipophilic triphenylphosphonium cat...
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Published in | Journal of labelled compounds & radiopharmaceuticals Vol. 56; no. 14; pp. 717 - 721 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English French German |
Published |
HOBOKEN
Blackwell Publishing Ltd
01.12.2013
Wiley Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Changes in the magnitude of the mitochondrial membrane potential occur in a range of important pathologies. To assess changes in membrane potential in patients, we set out to develop an improved mitochondria‐targeted positron emission tomography probe comprising a lipophilic triphenylphosphonium cation attached to a fluorine‐18 radionuclide via an 11‐carbon alkyl chain, which is well‐established to effectively transport to and localise within mitochondria. Here, we describe the radiosynthesis of this probe, 11‐[18F]fluoroundecyl‐triphenylphosphonium (MitoF), from no‐carrier‐added [18F]fluoride and a fully automated synthetic protocol to prepare it in good radiochemical yields (2–3 GBq at end‐of‐synthesis) and radiochemical purity (97–99%). Copyright © 2013 John Wiley & Sons, Ltd.
Radiosynthesis of the probe, 11‐[18F]fluoroundecyl‐triphenylphosphonium (MitoF), from no‐carrier‐added [18F]fluoride. |
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Bibliography: | Supporting info item Supporting information may be found in the online version of this article. ArticleID:JLCR3109 istex:4B07BEA7CC01B469E56A80A2B79228CE13C6D943 ark:/67375/WNG-XTMNLVMP-V researchfish UKRI ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0362-4803 1099-1344 |
DOI: | 10.1002/jlcr.3109 |