Association Between MRI Radiomics and Intratumoral Tertiary Lymphoid Structures in Intrahepatic Cholangiocarcinoma and Its Prognostic Significance

• Published in: Journal of magnetic resonance imaging Vol. 60; no. 2; pp. 715 - 728
• Main Authors: Xu, Ying, Li, Zhuo, Yang, Yi, Zhang, Yuwei, Li, Lu, Zhou, Yanzhao, Ouyang, Jingzhong, Huang, Zhen, Wang, Sicong, Xie, Lizhi, Ye, Feng, Zhou, Jinxue, Ying, Jianming, Zhao, Hong, Zhao, Xinming
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2024; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Bile Duct Neoplasms - diagnostic imaging; biomarkers; Cholangiocarcinoma; Cholangiocarcinoma - diagnostic imaging; Confidence intervals; Diffusion rate; Female; Humans; Image Processing, Computer-Assisted - methods; intrahepatic cholangiocarcinoma; Itk protein; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Middle Aged; Portal vein; Prognosis; Radiomics; Rank tests; Regression analysis; Regression models; Reproducibility of Results; Retrospective Studies; ROC Curve; Statistical analysis; Statistical tests; tertiary lymphoid structures; Tertiary Lymphoid Structures - diagnostic imaging; radiomics; magnetic resonance imaging; biomarkers; intrahepatic cholangiocarcinoma; tertiary lymphoid structures
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.29128

Background Tertiary lymphoid structures (TLSs) have prognostic value in intrahepatic cholangiocarcinoma (ICC) patients. Noninvasive tool to preoperatively evaluate TLSs is still lacking. Purpose To explore the association between TLSs status of ICC and preoperative MRI radiomics analysis. Study Type Retrospective. Subjects One hundred and ninety‐two patients with ICC, divided into training (T = 105), internal validation groups (V1 = 46), and external validation group (V2 = 41). Sequence Coronal and axial single‐shot fast spin‐echo T2‐weighted, diffusion‐weighted imaging, T1‐weighted, and T1WI fat‐suppressed spoiled gradient‐recall echo LAVA sequence at 3.0 T. Assessment The VOIs were drawn manually within the visible borders of the tumors using ITK‐SNAP version 3.8.0 software in the axial T2WI, DWI, and portal vein phase sequences. Radiomics features were subjected to least absolute shrinkage and selection operator regression to select the associated features of TLSs and construct the radiomics model. Univariate and multivariate analyses were used to identify the clinical radiological variables associated with TLSs. The performances were evaluated by the area under the receiver operator characteristic curve (AUC). Statistical Tests Logistic regression analysis, ROC and AUC, Hosmer–Lemeshow test, Kaplan–Meier method with the log‐rank test, calibration curves, and decision curve analysis. P < 0.05 was considered statistically significant. Results The AUCs of arterial phase diffuse hyperenhancement were 0.59 (95% confidence interval [CI], 0.50–0.67), 0.52 (95% CI, 0.43–0.61), and 0.66 (95% CI, 0.52–0.80) in the T, V1, and V2 cohorts. The AUCs of Rad‐score were 0.85 (95% CI, 0.77–0.92), 0.81 (95% CI, 0.67–0.94), and 0.84 (95% CI, 0.71–0.96) in the T, V1, and V2 cohorts, respectively. In cohort T, low‐risk group showed significantly better median recurrence‐free survival (RFS) than that of the high‐risk group, which was also confirmed in cohort V1 and V2. Data Conclusion A preoperative MRI radiomics signature is associated with the intratumoral TLSs status of ICC patients and correlate significantly with RFS. Level of Evidence 3 Technical Efficacy Stage 2