Multicomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4-Alkylthio-3-halo-2(5H)-furanones

An easy two-/three-component selective thioetherification of KSAc for the synthesis of a series of symmetrical/unsymmetrical 4-alkylthio-3-halo-2(5H)-furanones has been described. The reaction without any metal catalyst or additive is carried out in air atmosphere at room temperature for 5 h, only u...

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Published inAsian journal of organic chemistry Vol. 12; no. 3
Main Authors Zhou, Yong-Jun, Fang, Yong-Gan, Yang, Kai, Yu, Shi-Wei, Chen, Zu-Jia, Wang, Bi-Cheng, Zhan, Hai-Ying, Wang, Zhao-Yang
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 01.03.2023
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HALIDES
DESIGN
Potassium thioacetate
ONE-POT SYNTHESIS
C-S bond formation
DISCOVERY
2(5H)-furanones
SULFIDE
Transition-metal-free
CONSTRUCTION
THIOACETATES
Symmetrical
unsymmetrical synthesis
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Summary:An easy two-/three-component selective thioetherification of KSAc for the synthesis of a series of symmetrical/unsymmetrical 4-alkylthio-3-halo-2(5H)-furanones has been described. The reaction without any metal catalyst or additive is carried out in air atmosphere at room temperature for 5 h, only using potassium thioacetate as an odourless sulfur source and a base simultaneously. The broad substrate scope and high yield make it important for the studies on both constructing C-S bond based on non-aryl C-sp2-X bond and synthesizing new 2(5H)-furanone functional molecules.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202300038