The efficacy of microemulsion-based delivery to improve vitamin E properties: evaluation of the antinociceptive, antioxidant, antidepressant- and anxiolytic-like activities in mice

• Published in: Journal of pharmacy and pharmacology Vol. 70; no. 12; p. 1723
• Main Authors: Wilhelm, Ethel A, Vogt, Ane G, Reis, Angélica S, Pinz, Mikaela P, de Souza, Jaqueline F, Haas, Sandra E, Pereira, Albanin A M, Fajardo, André R, Luchese, Cristiane
• Format: Journal Article
• Language: English
• Published: England 01.12.2018
• Subjects: Analgesics - administration & dosage; Analgesics - pharmacology; Animals; Anti-Anxiety Agents - administration & dosage; Anti-Anxiety Agents - pharmacology; Antidepressive Agents - administration & dosage; Antidepressive Agents - pharmacology; Antioxidants - administration & dosage; Antioxidants - pharmacology; Behavior, Animal - drug effects; Drug Delivery Systems; Emulsions; Male; Mice; Vitamin E - administration & dosage; Vitamin E - pharmacology; antioxidant; anxiolytic; antinociceptive; microemulsion; antidepressant
• ISSN: 2042-7158
• DOI: 10.1111/jphp.13018

A microemulsion-based delivery system was designed to improve vitamin E (VE) properties, and its antinociceptive, antioxidant, antidepressant- and anxiolytic-like activities in mice were evaluated. Male Swiss mice received, by intragastric route, canola oil (20 ml/kg), blank microemulsion (B-ME) (20 ml/kg), VE free (VE-F) (200 mg/kg) or VE microemulsion (VE-ME) (200 mg/kg). In acute treatment, a single dose of treatments was administrated and 30 min after behavioural tests were performed. In the subchronic treatment, mice received such treatments, once a day, for 8 days. On the eighth day, behavioural tests were performed. In the subchronic treatment, VE-ME increased entries and spent time in the open arms in the elevated plus-maze test and decreased the immobility time in the tail suspension test, but no change was found after acute treatment. Acute and subchronic treatments with VE-ME increased response latency to thermal stimulus in the hot-plate test. VE-ME decreased the thiobarbituric acid reactive species levels in the acute and subchronic protocols. Additionally, in subchronic treatment, VE-ME increased renal catalase activity, but VE-F reduced its activity. Vitamin E-microemulsions showed antioxidant, antinociceptive, antidepressant- and anxiolytic-like actions; thus, ME-based delivery improved pharmacological properties of VE.