Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease

• Published in: Journal of pharmacy and pharmacology Vol. 69; no. 9; p. 1219
• Main Authors: Ali, Badreldin H, Cahliková, Lucie, Opletal, Lubomir, Karaca, Turan, Manoj, Priyadarsini, Ramkumar, Aishwarya, Al Suleimani, Yousuf M, Al Za'abi, Mohammed, Nemmar, Abderrahim, Chocholousova-Havlikova, Lucie, Locarek, Miroslav, Siatka, Tomas, Blunden, Gerald
• Format: Journal Article
• Language: English
• Published: England 01.09.2017
• Subjects: Adenine - toxicity; Administration, Oral; Animals; Anthocyanins - administration & dosage; Anthocyanins - isolation & purification; Anthocyanins - pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Hibiscus - chemistry; Lisinopril - pharmacology; Male; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Rats; Rats, Wistar; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - physiopathology; Hibiscus sabdariffa; chronic kidney disease; rats; anthocyanins; adenine
• ISSN: 2042-7158
• DOI: 10.1111/jphp.12748

The aim of this work was to assess the possible beneficial effects of aqueous extracts of Hibiscus sabdariffa L. calyces and anthocyanins isolated therefrom in an adenine-induced chronic kidney disease (CKD) model. Rats were orally given, for 28 consecutive days, either adenine alone or together with either aqueous extract of H. sabdariffa calyces (5 and 10%) or anthocyanins (50, 100 and 200 mg/kg of anthocyanin concentrate). For comparative purposes, two groups of rats were given lisinopril (10 mg/kg). When either H. sabdariffa aqueous extract or the anthocyanins isolated from it was administered along with adenine, the adverse effects of adenine-induced CKD were significantly lessened, mostly in a dose-dependent manner. The positive effects were similar to those obtained by administration of lisinopril. The results obtained show that both H. sabdariffa and its anthocyanins could be considered as possible promising safe dietary agents that could be used to attenuate the progression of human CKD. This could have added significance as H. sabdariffa tea is widely consumed in many parts of Africa and Asia and is thus readily available.