MRI Assessment of Brain Frailty and Clinical Outcome in Patients With Acute Posterior Perforating Artery Infarction

• Published in: Journal of magnetic resonance imaging Vol. 59; no. 1; pp. 340 - 349
• Main Authors: Duan, Qi, Lyu, Jinhao, Cheng, Kun, Wang, Xueyang, Meng, Zhihua, Wu, Xiaoyan, Chen, Wen, Wang, Guohua, Niu, Qingliang, Li, Xin, Bian, Yitong, Han, Dan, Guo, Weiting, Yang, Shuai, Bian, Xiangbing, Lan, Yina, Wang, Liuxian, Zhang, Tingyang, Duan, Caohui, Tian, Chenglin, Lou, Xin
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2024; Wiley Subscription Services, Inc
• Subjects: Angiography; Arteries; Attention; Basal ganglia; Brain; Brain - diagnostic imaging; brain frailty; Cerebral infarction; Circulation; Confidence intervals; Diffusion rate; Female; Field strength; Flight; Frailty; Frailty - diagnostic imaging; Ganglia; Humans; Infarction; Magnetic Resonance Imaging; Male; Medical imaging; Neuroimaging; Perforating; perforating artery infarction; Population studies; posterior circulation; prognosis; Prospective Studies; Statistical analysis; Statistical tests; Substantia alba; perforating artery infarction; posterior circulation; prognosis; brain frailty
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.28768

Background Global brain health has gained increasing attention recently. Imaging markers of brain frailty have been related to functional outcomes in previous studies on anterior circulation; however, little data are available on imaging markers and posterior circulation. Purpose To investigate the impact of brain frailty on functional outcomes in patients with acute perforating artery infarction (PAI) of the posterior circulation. Study Type Prospective. Population One hundred patients (60.78 ± 9.51 years, 72% men) with acute posterior circulation PAI (determined by diffusion‐weighted magnetic resonance imaging (MRI)/time‐of‐flight MR angiography). Field Strength/Sequence T1‐ and T2‐weighted fast spin echo, T2‐weighted fluid‐attenuated inversion recovery, diffusion‐weighted echo planar, gradient echo (susceptibility‐weight imaging), and 3D time‐of‐flight MR angiography sequences at 3.0 T. Assessment Periventricular and deep white matter hyperintensities (WMH), enlarged perivascular spaces (EPVS) in the basal ganglia and centrum semiovale area, lacunes, cerebral microbleeds (CMB), and total brain frailty score by calculating the above imaging characters were rated visually by three radiologists with 9, 10, and 11 years of experience and one neuroradiologist with 12. Infarction volume was assessed using baseline diffusion‐weighted imaging (DWI) data obtained within 24 hours of symptom onset. A modified Rankin Scale (mRS) score >1 on day 90 defined an adverse functional outcome. Associations between the imaging markers of brain frailty and functional outcomes were assessed. Statistical Tests Fisher's exact test, Mann–Whitney U test, and multivariable binary logistic regression. A P value <0.05 was considered statistically significant. Results Adverse prognoses (mRS > 1) were observed in 34 (34%) patients. Infarction volume, periventricular WMH, deep WMH, basal ganglia EPVS, CMB, and the brain frailty score were significantly associated with adverse functional outcomes. An increased brain frailty score was significantly associated with unfavorable mRS score on day 90 (odds ratio 1.773, 95% confidence interval 1.237–2.541). Data Conclusion Advanced MRI imaging markers of brain frailty, individually or combined as a total brain frailty score, were associated with worse functional outcomes after acute posterior circulation PAI. Level of Evidence 3 Technical Efficacy Stage 3