Effect of compliance during periodontal maintenance therapy on c‐reactive protein levels: a 6‐year follow‐up

• Published in: Journal of clinical periodontology Vol. 48; no. 3; pp. 400 - 409
• Main Authors: Costa, Fernando Oliveira, Esteves Lima, Rafael Paschoal, Cortelli, Sheila Cavalca, Costa, Adriana Moreira, Cortelli, José Roberto, Cota, Luís Otávio Miranda
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.03.2021
• Subjects: C-Reactive Protein; compliance; Dentistry; Follow-Up Studies; Gum disease; Humans; Longitudinal Studies; maintenance; Periodontitis; Periodontitis - drug therapy; Plasma levels; Prospective Studies; C-reactive protein; maintenance; compliance; periodontitis
• ISSN: 0303-6979; 1600-051X
• DOI: 10.1111/jcpe.13407

Aims To longitudinally evaluate the effects of compliance during periodontal maintenance therapy (PMT) on C‐reactive protein (CRP) levels and its relation to periodontal status. Materials and Methods A subsample comprising of 30 matched pairs was taken from a previous 6‐year longitudinal study under PMT. Pairs were composed of one regular (RC) and one irregular (IC) compliers, matched by age and sex. Periodontal parameters and plasma samples were collected at 3 times: T1[prior to active periodontal therapy (APT)], T2(after APT), and T3(after 6 years). CRP plasma levels were quantified using ELISA. Results RC presented better clinical periodontal status, lower recurrence of periodontitis (sites with PD ≥4 mm and CAL ≥3 mm, together with the persistence and/or presence of BOP and/or suppuration, during any of the subsequent recall evaluations) and significant reductions in CRP levels over time [(T1: RC = 3.64 ± 2.13 and IC = 3.92 ± 2.02 mg/L) and (T3: RC = 2.12 ± 1.39 mg/L and IC = 3.71 ± 1.82 mg/L)]. Logistic regression analysis demonstrated that individuals with periodontitis recurrence presented 2.19 higher chances of presenting altered CRP levels (values ≥3 mg/L‐ T2 to T3) than those without periodontitis recurrence (95%CI:1.16–3.27; p = 0.017). Conclusions Higher CRP plasma levels were associated with higher recurrence of periodontitis and worse clinical periodontal parameters among IC when compared to RC.