Deoxyfluorination of (Hetero)aryl Aldehydes Using Tetramethylammonium Fluoride and Perfluorobutanesulfonyl Fluoride or Trifluoromethanesulfonic Anhydride

This Communication describes the conversion of (hetero)aryl aldehydes into the corresponding (hetero)aryl difluoromethyl products using anhydrous NMe4F in combination with perfluorobutanesulfonyl fluoride or trifluoromethanesulfonic anhydride.

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Bibliographic Details
Published inIsrael journal of chemistry Vol. 60; no. 3-4; pp. 398 - 401
Main Authors Ferguson, Devin M., Melvin, Patrick R., Sanford, Melanie S.
Format Journal Article
LanguageEnglish
Published Haifa Wiley Subscription Services, Inc 01.03.2020
Subjects
Aldehydes
Anhydrides
Aromatic compounds
deoxyfluorination
difluoromethylation
Fluorides
fluorination
fluoroalkylation
tetramethylammonium fluoride
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Summary:This Communication describes the conversion of (hetero)aryl aldehydes into the corresponding (hetero)aryl difluoromethyl products using anhydrous NMe4F in combination with perfluorobutanesulfonyl fluoride or trifluoromethanesulfonic anhydride.
ISSN:0021-2148
1869-5868
DOI:10.1002/ijch.201900066