Liquid‐Like Phases Preorder Peptides for Supramolecular Assembly

The front cover artwork is provided by our research group at Emory University, Atlanta (USA). The image depicts the diverse array of single β‐sheets that we have identified spectroscopically existing within metastable solute‐rich peptide phases. As the particle phase grows in time, sheet‐sheet stack...

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Bibliographic Details
Published inChemSystemsChem Vol. 2; no. 6
Main Authors Rengifo, Rolando F., Sementilli, Anthony, Kim, Youngsun, Liang, Chen, Xiang'An Li, Noel, Mehta, Anil K., Lynn, David G.
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.11.2020
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Summary:The front cover artwork is provided by our research group at Emory University, Atlanta (USA). The image depicts the diverse array of single β‐sheets that we have identified spectroscopically existing within metastable solute‐rich peptide phases. As the particle phase grows in time, sheet‐sheet stacking appears to nucleate fibril assembly. Read the full text of the Communication at 10.1002/syst.202000007. “We present spectroscopic analyses of metastable phases formed with a congener of the Alzheimer's disease Aβ peptide that reveal diverse populations of single β‐sheets. The degree of order in this liquid‐like particle phase is remarkable both in the range of sheets and the selection of a single propagating nucleus…” This and more about the story behind the front cover can be found in the Communication at 10.1002/syst.202000007.
ISSN:2570-4206
2570-4206
DOI:10.1002/syst.202000046