Quercetin-Coating Promotes Osteogenic Differentiation, Osseointegration and Anti-Inflammatory Properties of Nano-Topographic Modificated 3D-Printed Ti6Al4V Implant
The capabilities of osseointegration and anti-inflammatory properties are of equal significance to the bio-inert titanium implant surface. Quercetin has proved its capacities of activating anti-inflammation through macrophage modulation and promoting osteogenic differentiation. Herein, we fabricated...
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Published in | Frontiers in bioengineering and biotechnology Vol. 10; p. 933135 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
08.06.2022
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Subjects | |
Online Access | Get full text |
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Summary: | The capabilities of osseointegration and anti-inflammatory properties are of equal significance to the bio-inert titanium implant surface. Quercetin has proved its capacities of activating anti-inflammation through macrophage modulation and promoting osteogenic differentiation. Herein, we fabricated quercetin-coating on nano-topographic modificated 3D-printed Ti6Al4V implant surface. Subsequently the biological cells responses
in vitro
, anti-inflammatory and osseointegration performance
in vivo
were evaluated.
In vitro
studies indicated that quercetin-coating can enhance the adhesion and osteogenic differentiation of rBMSCs, while modulating the polarization of macrophages from M1 to M2 phase and improving the anti-inflammatory and vascular gene expression. Moreover, quercetin-loaded implants reduced the level of peri-implant inflammation and ameliorated new bone formation and rapid osseoinegration
in vivo
. Quercetin-coating might provide a feasible and favorable scheme for endowing 3D-printed titanium alloy implant surface with enhanced the rapid osseointegration and anti-inflammatory properties. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology Dejian Li, Fudan University Pudong Medical Center, China Edited by: Gang Wu, VU Amsterdam, Netherlands These authors have contributed equally to this work Reviewed by: Zhihong Dong, Chengdu University, China |
ISSN: | 2296-4185 2296-4185 |
DOI: | 10.3389/fbioe.2022.933135 |