Improved Anti-Inflammatory Properties for Naproxen with Cyclodextrin-Grafted Polysaccharides

• Published in: Macromolecular bioscience Vol. 6; no. 7; pp. 555 - 561
• Main Authors: Ramírez, Héctor L., Cao, Roberto, Fragoso, Alex, Torres-Labandeira, Juan J., Dominguez, Amalia, Schacht, Etienne H., Baños, Maysa, Villalonga, Reynaldo
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 14.07.2006; WILEY‐VCH Verlag; Wiley-VCH
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Applied sciences; Biological and medical sciences; carboxymethylcellulose; Carboxymethylcellulose Sodium - chemistry; Carrageenan - metabolism; cyclodextrins; Cyclodextrins - chemistry; drug delivery systems; Exact sciences and technology; Fluorescence; General pharmacology; Magnetic Resonance Spectroscopy; Male; mannan; Mannans - chemistry; Medical sciences; Naproxen; Naproxen - chemical synthesis; Naproxen - chemistry; Naproxen - pharmacology; Natural polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Rats; Rats, Wistar; Solubility; Starch and polysaccharides; supramolecular interactions; Cellulose(carboxymethyl); Graft copolymer; Control release polymer; Drug carrier; Stability constant; Experimental study; Biological activity; Mannan; Chemical coupling; Non steroidal antiinflammatory agent; In vivo; Cyclodextrin; Chemical modification; Naproxen; Preparation; Concentration effect; Oside polymer; Inclusion compound; Cellulose ether
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.200600023

Mannan and carboxymethylcellulose, previously activated by periodate oxidation, were grafted with mono‐6‐butylenediamino‐6‐deoxy‐β‐cyclodextrin derivatives by reductive alkylation in the presence of sodium borohydride. The formation of supramolecular complexes between these polymers and Naproxen was confirmed by fluorescence spectroscopy. The solubility of the drug was 3.8–4.6 fold increased in the presence of the cyclodextrin‐grafted polysaccharides. The in vivo anti‐inflammatory property of Naproxen was 1.7 times higher after supramolecular association with β‐cyclodextrin‐branched mannan.