Prevalence and factors associated with urinary incontinence in females with cystic fibrosis: An Italian single‐center cross‐sectional analysis

Background Individuals with cystic fibrosis (CF) are deemed to have a higher risk of developing urinary incontinence (UI), likely due to repeated increasing pressure on the pelvic floor. We aimed to determine the prevalence of female UI in a large CF referral center, and to assess the association be...

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Published inPediatric pulmonology Vol. 57; no. 1; pp. 132 - 141
Main Authors Mariani, Alessandra, Gambazza, Simone, Carta, Federica, Ambrogi, Federico, Brivio, Anna, Bulfamante, Anna M., Daccò, Valeria, Bassotti, Giacomo, Colombo, Carla
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.01.2022
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Summary:Background Individuals with cystic fibrosis (CF) are deemed to have a higher risk of developing urinary incontinence (UI), likely due to repeated increasing pressure on the pelvic floor. We aimed to determine the prevalence of female UI in a large CF referral center, and to assess the association between UI and severity of CF disease. Methods We consecutively recruited female patients regularly attending our CF center, aged ≥6 years and with a confirmed diagnosis of CF. Prevalence, severity, and impact of UI were assessed by administering two validated questionnaires. Relationship between variables was evaluated by means of multiple correspondence analysis, whereas a logistic model was fitted to capture the statistical association between UI and independent variables. Results UI was present in 51/153 (33%, 95% confidence interval [CI]: 26%–41%) females. Among children and adolescents, the prevalence was 12/82 (15%, 95% CI: 8%–25%) whereas among adults was 39/71 (55%, 95% CI: 43%–67%). The only explanatory variable associated with UI was age, with children presenting the lowest risk (odds ratio, 0.32; 95% CI: 0.05–0.93). Females presenting low or high nutritional status show higher profile risk of having UI. Conclusions Stress UI is a common complication in females with CF since childhood. Although it frequently occurs in older patients with a more severe phenotype, much attention should be paid to adults and to their nutritional status.
Bibliography:Alessandra Mariani and Simone Gambazza contributed equally as first author.
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content type line 23
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.25723