Controlled attenuation parameter in the diagnosis of different liver steatosis groups in children with obesity

• Published in: Pediatric obesity Vol. 17; no. 6; pp. e12893 - n/a
• Main Authors: Yang, Lin, Lin, Yan, Zhu, Ya Fei, Zhu, Yin Yan, Liang, Zhen Ming, Wu, Guang Sheng
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Inc 01.06.2022; Wiley Subscription Services, Inc
• Subjects: CAP; children with obesity; Childrens health; Fatty liver; hepatic steatosis; Liver; Magnetic resonance imaging; MRI‐PDFF; NAFLD; Obesity; Pediatrics; Regression analysis; NAFLD; CAP; children with obesity; MRI-PDFF; hepatic steatosis
• ISSN: 2047-6302; 2047-6310; 2047-6310
• DOI: 10.1111/ijpo.12893

Summary Objective To investigate the utility of the controlled attenuation parameter (CAP), as measured by a liver elastography technique, in predicting varying degrees of liver steatosis in children with obesity. Methods Children with obesity attending the pediatric obesity clinic at the Affiliated Hospital of Hangzhou Normal University from July 2020 to May 2021 were retrospectively analysed. The 71 subjects were divided into four groups according to the degree of liver steatosis obtained by magnetic resonance imaging‐proton density fat fraction (MRI‐PDFF). The gender, age, CAP, LSM, ALT, AST, BMI, uric acid, fasting blood glucose, total cholesterol, triglyceride, high‐density lipoprotein, low‐density lipoprotein, insulin, and blood 25‐hydroxyvitamin D levels of the four groups were compared, and the differences were analysed. Clinical data with significant differences were included in the logistic regression analysis. The receiver operating characteristic (ROC) curve for the CAP for the 71 subjects with different degrees of liver steatosis was plotted to evaluate the diagnostic value. Results The 71 children were divided into groups according to the degree of hepatic steatosis obtained by MRI‐PDFF, and the clinical data for each group were compared. It was found that there was statistical significance for CAP, ALT, and AST in cases of moderate and severe hepatic steatosis (p < 0.05). Logistic regression analysis was conducted between CAP, ALT, AST, and moderate to severe hepatic steatosis in children with obesity, and it was found that CAP was a factor related to moderate to severe hepatic steatosis in children with obesity. The ROC curve indicated that CAP has diagnostic value for NAFLD in children with obesity. Conclusion There is diagnostic value in the use of CAP for hepatic steatosis in children with obesity, and there is greater diagnostic value in the use of CAP for children with moderate to severe hepatic steatosis.