Effect of Lactobacillus plantarum P-8 on lipid metabolism in hyperlipidemic rat model

• Published in: European journal of lipid science and technology Vol. 114; no. 11; pp. 1230 - 1236
• Main Authors: Bao, Yan, Wang, Zhanli, Zhang, Yong, Zhang, Jiachao, Wang, Lifeng, Dong, Ximei, Su, Fang, Yao, Guoqiang, Wang, Shuiquan, Zhang, Heping
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.11.2012; WILEY‐VCH Verlag; Wiley-VCH
• Subjects: Biological and medical sciences; Fat industries; Food industries; Fundamental and applied biological sciences. Psychology; Intestinal microflora; Lactobacillus plantarum P-8; Lipid metabolism; Probiotics; Oils and fats industry; Probiotics; Vertebrata; Mammalia; Rat; Rodentia; Lipids; Models; Lactobacillus plantarum P-8; Intestinal microflora; Lipid metabolism; Metabolism
• ISSN: 1438-7697; 1438-9312
• DOI: 10.1002/ejlt.201100393

Probiotics have been reported to play an important role in the prevention of metabolic disorders. We recently identified a novel probiotic strain Lactobacillus plantarum (L. plantarum) P‐8. The objective of this study was to determine the effects of L. plantarum P‐8 on lipid metabolism of rats fed with high fat diet. All experimental rats were divided into three groups: control group, model group, and L. plantarum P‐8 group. Changes in serum lipid levels, hepatic lipid deposition, serum oxidative stress‐related parameters, activities of liver function marker enzymes, organ indices, gut microflora, and fecal lipids were assessed. Compared with model group, L. plantarum P‐8 exhibited hypolipidemic effects by lowering serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol levels, accompanied with elevation of high‐density lipoprotein cholesterol level. L. plantarum P‐8 also exerted beneficial effects against high‐fat diet‐induced oxidative stress, curtailed the accumulation of liver lipids and protected healthy liver function. Moreover, L. plantarum P‐8 was able to regulate intestinal bacteria and enhance the fecal excretion of TC, TG, and bile acid. These findings indicate that L. plantarum P‐8 may represent a potential therapeutic agent for controlling hyperlipidemia. Hepatic lipid deposition in the control, model, and L. plantarum P‐8 group shown using HE staining.