The Association of Salivary Serotonin With Mood and Cardio-Autonomic Function: A Preliminary Report
Background Serotonin plays an important role in mood regulation and depression. However, it is not clear whether the levels of serotonin in saliva are related to current mood. Aim To test the association of salivary serotonin concentrations with mood, as well as cardiovascular and autonomic paramete...
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| Published in | Frontiers in psychiatry Vol. 13; p. 788153 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
31.05.2022
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Background
Serotonin plays an important role in mood regulation and depression. However, it is not clear whether the levels of serotonin in saliva are related to current mood.
Aim
To test the association of salivary serotonin concentrations with mood, as well as cardiovascular and autonomic parameters.
Materials and Methods
Saliva samples were obtained from collegiate runners and output parameters were examined before and after physical activity.
Results
Salivary serotonin concentration was negatively associated with current mood (β = −0.32, 95%CI −0.62 to −0.02,
p
= 0.037, analysis adjusted for potential confounders), but insignificantly with measured cardiovascular and autonomic parameters.
Conclusions
Salivary serotonin may reflect current mood. The results are preliminary and require further evaluation. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Philip Cowen, University of Oxford, United Kingdom; Paul J. Marvar, George Washington University, United States This article was submitted to Molecular Psychiatry, a section of the journal Frontiers in Psychiatry Edited by: Trevor Ronald Norman, The University of Melbourne, Australia |
| ISSN: | 1664-0640 1664-0640 |
| DOI: | 10.3389/fpsyt.2022.788153 |