Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on disease pathophysiology is essential for enhancing their therapeutic effects in periodontitis treatment. As promising localized drug d...

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Bibliographic Details
Published inAdvanced functional materials Vol. 33; no. 30
Main Authors Yin, Yuanyuan, Yang, Sihan, Ai, Dongqing, Qin, Han, Sun, Yu, Xia, Xuyun, Xu, Xiaohui, Ji, Wei, Song, Jinlin
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc 01.07.2023
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Summary:Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on disease pathophysiology is essential for enhancing their therapeutic effects in periodontitis treatment. As promising localized drug delivery systems and tissue engineering scaffolds, hydrogels have gained significant interest for controlled and sustained release of bioactive agents in periodontal applications. The rational design of bioactive hydrogels can facilitate bacterial control and modulate destructive host inflammation, thereby preventing the progression of periodontitis. In this review, the pathophysiological mechanisms underlying periodontitis as fundamental principles for the design of functional hydrogel systems are first introduced. In the following part, an overview is systematically provided of the types and functions of the bioactive hydrogel systems loaded with anti‐bacterial and anti‐inflammatory agents for periodontal delivery. Finally, the remaining challenges and future perspectives of hydrogel delivery systems for periodontal applications are proposed. It is believed that this review will inspire the rational design and development of innovative functional hydrogel biomaterials toward periodontal therapy. This review focuses on the rational design and research advances of bioactive hydrogel delivery systems loaded with anti‐bacterial and/or anti‐inflammatory agents for periodontitis treatment. The pathophysiological mechanisms underlying periodontitis, including bacterial biofilm formation and host inflammatory response, are highlighted as guiding principles for the design of bioactive hydrogels to combat bacterial infection and modulate host inflammation.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202301062