Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

• Published in: International journal of clinical practice (Esher) Vol. 75; no. 7; pp. e14232 - n/a
• Main Authors: Dalbaşı, Erkan, Akgül, Ömer Lütfi
• Format: Journal Article
• Language: English
• Published: England Hindawi Limited 01.07.2021
• Subjects: Abdomen; Antibiotics; Appendectomy; Appendicitis; Appendix; Computed tomography; Edema; Laparoscopy; Medical treatment; Patients; Platelets; Statistical analysis; Surgery
• ISSN: 1368-5031; 1742-1241
• DOI: 10.1111/ijcp.14232

Background Acute appendicitis (AA) is the most common cause of surgery performed for the acute abdomen. The standard treatment for AA patients has been appendectomy for more than a century. The use of broad‐spectrum antibiotics, the medical treatment option has come to the fore in the treatment of uncomplicated AA. Aim Evaluate whether white blood cell (WBC), platelet count, mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW) and C‐reactive protein (CRP) values of patients diagnosed with uncomplicated AA clinically, with laboratory tests and radiologically with abdominal computed tomography (CT) could be a marker for choosing medical or surgical treatment. Materials and Methods 519 patients aged between 20 and 65 years who were diagnosed with uncomplicated AA by abdominal CT in our centre between January 2016 and January 2019 were retrospectively analysed. The presence of at least one of the criteria of 7 mm or more appendix diameter and oedema or fluid accumulation around the appendix was accepted as uncomplicated AA. After the diagnosis of AA, 223 patients were treated medically, while 296 patients underwent laparoscopic appendectomy. The first group included patients who were treated medically and the second group included patients who underwent laparoscopic appendectomy. Results Group 2 patients had higher mean platelet count (P < .005) and RDW (P = .003) values compared to Group 1 patients, while mean PDW (P < .001) values were lower compared to those of Group 1 patients. The differences between the mean WBC, CRP and MPV values of the groups were not statistically significant (P > .05). Conclusions Recently, studies supporting antibiotic therapy have been conducted in patients diagnosed with AA. As a result, we think that PDW, RDW, and platelet values in patients diagnosed with uncomplicated AA may be a guide in choosing patients to be treated with surgery or antibiotics.