Cera‐Glow, ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201, improves skin barrier function in clinical study

• Published in: Journal of cosmetic dermatology Vol. 22; no. 6; pp. 1879 - 1886
• Main Authors: Lee, Minjee, Kim, Myun Soo, Jang, Sung Hee, Kim, Hayoung, Kim, Gwang Seob, Lee, Hyerin, Park, Hyun Min, Yang, Jungwoo
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2023
• Subjects: Age; Cosmetics; Dermatologic Agents - pharmacology; Dermatology; Edema; Epidermis; Erythema; Female; Humans; Hydration; Lacticaseibacillus; Lacticaseibacillus rhamnosus; Moisture content; Probiotics; Questionnaires; Self evaluation; Skin; skin barrier; Skin diseases; skin hydration; transepidermal water loss; Variance analysis; Water - metabolism; Womens health; skin barrier; Lacticaseibacillus rhamnosus; transepidermal water loss; skin hydration
• ISSN: 1473-2130; 1473-2165
• DOI: 10.1111/jocd.15642

Background Ceramides are essential lipids in stratum corneum for skin permeability barrier function in that they retain the skin moisture and protect from the invasion of foreign pathogens. Previously, we demonstrated that ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201 enhanced ceramide production in human epidermal keratinocytes. Furthermore, for comprehensive knowledge of this effect, in vitro experiments and multi‐omics analysis were conducted to explore the underlying mechanisms. Aims This study was designed to identify whether a cosmetic sample (i.e., Cera‐Glow) containing the lysates improves the skin barrier function in clinical trials. Patients/Methods Twenty‐four female participants (45.46 ± 9.78 years) had been enrolled in the transepidermal water loss (TEWL) measurement for 5 days and 21 female participants (50.33 ± 5.74 years) had undergone a skin hydration evaluation for 4 weeks. TEWL and skin hydration were evaluated using a Tewameter and the Epsilon Permittivity Imaging System, respectively. After applying the Cera‐Glow sample, all participants recorded a satisfaction survey questionnaire (e.g., satisfaction, efficacy, and adverse reactions). Results Application of Cera‐Glow significantly improved transepidermal water loss induced by 1% (w/v) sodium lauryl sulfate (p < 0.05–0.01) and increased skin hydration (p < 0.01). Metabolic analysis suggested that Cera‐Glow should contain beneficial gradients for skin barrier function. According to the questionnaire, most of participants were satisfied with the skin hydration improvement and efficacy of Cera‐Glow. Conclusions Cera‐Glow, ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201, can significantly improve skin barrier function.