Diffusion‐Weighted Imaging Distinguishes Between Osteomyelitis, Bone Marrow Edema, and Healthy Bone on Forefoot Magnetic Resonance Imaging

• Published in: Journal of magnetic resonance imaging Vol. 56; no. 5; pp. 1571 - 1579
• Main Authors: Kruk, Konrad A., Dietrich, Tobias J., Wildermuth, Simon, Leschka, Sebastian, Toepfer, Andreas, Waelti, Stephan, Kim, Chan‐Hi Olaf, Güsewell, Sabine, Fischer, Tim
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2022; Wiley Subscription Services, Inc
• Subjects: Bone imaging; Bone marrow; Bone Marrow - diagnostic imaging; Bone Marrow - pathology; bone marrow diseases; Bone Marrow Diseases - diagnostic imaging; Correlation coefficient; Correlation coefficients; Diffusion; Diffusion coefficient; diffusion magnetic resonance imaging; Diffusion Magnetic Resonance Imaging - methods; Edema; Edema - diagnostic imaging; Evaluation; Field strength; Humans; Magnetic Resonance Imaging; Mathematical analysis; Medical imaging; Osteomyelitis; Osteomyelitis - diagnostic imaging; Prospective Studies; Resonance; Sensitivity and Specificity; Statistical analysis; Statistical tests; osteomyelitis; bone marrow diseases; diffusion magnetic resonance imaging; magnetic resonance imaging
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.28091

Background Diagnosis of osteomyelitis by imaging can be challenging. The feasibility of diffusion‐weighted imaging (DWI) as ancillary sequence was evaluated in this study. Purpose To evaluate DWI for differentiation between osteomyelitis, bone marrow edema, and healthy bone on forefoot magnetic resonance imaging (MRI). Study type Prospective. Subjects A total of 60 consecutive patients undergoing forefoot MRI divided into three study groups (20 subjects each): osteomyelitis, bone marrow edema, and healthy bone. Field strength/Sequence A 1.5T and 3T MRI scanners; readout‐segmented multishot echo planar DWI. Assessment Two independent radiologists measured apparent diffusion coefficient (ADC) values within abnormal or healthy bone. Statistical Tests ADC values were compared between groups (pairwise t‐test with Bonferroni‐Holm correction for multiple testing). Intraclass correlation coefficient (ICC) was calculated to assess inter‐reader agreement. Threshold ADC values were determined as the cutoffs that maximized the sum of sensitivity and specificity. Receiver operating characteristic (ROC) analysis was performed with statistical threshold of P < 0.05. Results Inter‐reader agreement was 0.92 in the healthy bone group and 0.78 in both the edema and osteomyelitis groups. Average ADC values were significantly different between groups: 1432 ± 222 × 10−6 mm2/sec (osteomyelitis), 1071 ± 196 × 10−6 mm2/sec (bone marrow edema), and 277 ± 89 × 10−6 mm2/sec (healthy bone). A threshold ADC value of 534 × 10−6 mm2/sec distinguishes between healthy and abnormal bone with specificity and sensitivity of 100% each. For distinction between osteomyelitis and bone marrow edema, two cutoff values were determined: a 95%‐specificity cutoff indicating osteomyelitis (>1320 × 10−6 mm2/sec) and a 95%‐sensitivity cutoff indicating bone marrow edema (<1155 × 10−6 mm2/sec). Diagnostic accuracy of 95% was achieved for 73% (29/40) of the subjects. Data Conclusion DWI with ADC maps distinguishes between healthy and abnormal bone on forefoot MRI. Calculated cutoff values allow confirmation or exclusion of osteomyelitis in a high proportion of subjects. Evidence Level 2 Technical Efficacy Stage 2