Photocatalytic Regio‐ and Site‐Selective Alkylamination of Coumarins: Access to 3‐Amino‐ and 4‐Amino Dihydrocoumarins

Functionalized dihydrocoumarins, including 3‐amino‐ and 4‐amino dihydrocoumarins serving as α‐ and β‐amino acid derivatives, have been synthesized using one‐step site‐ and regioselective alkylamination from coumarins. This conversion offers 35 examples in 24% to 81% yields.

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 365; no. 7; pp. 997 - 1001
Main Authors Jiang, Yu‐Shi, Liang, Feng, Chen, Ai‐Min, Li, Shan‐Shan, Luo, Xue‐Ling, Xia, Peng‐Ju
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 11.04.2023
Wiley Subscription Services, Inc
Subjects
Alkylamination
Amino acids
Chemistry
Chemistry, Applied
Chemistry, Organic
Dihydrocoumarins
Photocatalytic
Physical Sciences
Science & Technology
Site-selective
Photocatalytic
ALKENES
Alkylamination
ENANTIOSELECTIVE SYNTHESIS
Site-selective
Dihydrocoumarins
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Summary:Functionalized dihydrocoumarins, including 3‐amino‐ and 4‐amino dihydrocoumarins serving as α‐ and β‐amino acid derivatives, have been synthesized using one‐step site‐ and regioselective alkylamination from coumarins. This conversion offers 35 examples in 24% to 81% yields.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202201391