The use of a liposomally entrapped enzyme in the treatment of an artificial storage condition

A model storage condition has been produced by the intraperitoneal administration of dextran to rats; dextran accumulates in the liver, in all cellular compartments, and remains there for an extended period because of the absence of a dextranase in rats. The intravenous administration of dextranase...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 451; no. 2; pp. 417 - 425
Main Authors Colley, C.Michael, Ryman, Brenda E.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 21.12.1976
Subjects
Animals
Dextranase - deficiency
Dextranase - therapeutic use
Dextrans - metabolism
Disease Models, Animal
Liposomes - therapeutic use
Liver - metabolism
Male
Rats
Subcellular Fractions - metabolism
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Summary:A model storage condition has been produced by the intraperitoneal administration of dextran to rats; dextran accumulates in the liver, in all cellular compartments, and remains there for an extended period because of the absence of a dextranase in rats. The intravenous administration of dextranase entrapped in liposomes produces a rapid decrease in the amount of dextran in the liver.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0304-4165
0006-3002
1872-8006
DOI:10.1016/0304-4165(76)90136-7