Alteration of cyclic nucleotide levels in brain following intracranial self-stimulation in the rat

In a first experiment, 14 rats were implanted with an electrode in the ventral tegmental area and trained to self-stimulate. On the experimental day only half of the rats were allowed to self-stimulate for one hour. All rats were then sacrificed by immersion in liquid nitrogen. Seven brain regions w...

Full description

Saved in:
Bibliographic Details
Published inPharmacology, biochemistry and behavior Vol. 11; no. 1; pp. 107 - 110
Main Authors Miliaressis, Eleftherios, Merali, Zulfiquar
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.1979
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:In a first experiment, 14 rats were implanted with an electrode in the ventral tegmental area and trained to self-stimulate. On the experimental day only half of the rats were allowed to self-stimulate for one hour. All rats were then sacrificed by immersion in liquid nitrogen. Seven brain regions were dissected and assayed for the endogenous concentration of cyclic nucleotides. Self-stimulation induced significant changes in striatum and hippocampus. However, a subsequent experiment showed that the same pattern of changes in the striatum can be produced by motor activity. On the other hand, changes in the hippocampus were specific to the self-stimulation group suggesting that this structure is associated with the brain reward system.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(79)90305-8