Antimicrobial peptides as an alternative to anti-tuberculosis drugs

[Display omitted] Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite the introduction four decades ago of the affordable and efficient four-drugs (isoniazid, rifampicin, pyrazinamide and ethambutol). Thus, a strong need exists for new drugs with special struc...

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Published inPharmacological research Vol. 128; pp. 288 - 305
Main Authors AlMatar, Manaf, Makky, Essam A., Yakıcı, Gülfer, Var, Işıl, Kayar, Begüm, Köksal, Fatih
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.02.2018
Subjects
Animals
Anti-Infective Agents - pharmacology
Antimicrobial Cationic Peptides - chemistry
Antimicrobial Cationic Peptides - pharmacology
Antimicrobial Cationic Peptides - therapeutic use
Antimicrobial peptides (AMPs)
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
Drug Delivery Systems
Humans
Mycobacterium - drug effects
New anti-tuberculosis drugs
Synergistic effect
Tuberculosis
Tuberculosis - drug therapy
Antimicrobial peptides (AMPs)
Tuberculosis
New anti-tuberculosis drugs
Synergistic effect
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Summary:[Display omitted] Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite the introduction four decades ago of the affordable and efficient four-drugs (isoniazid, rifampicin, pyrazinamide and ethambutol). Thus, a strong need exists for new drugs with special structures and uncommon modes of action to effectively overcome M. tuberculosis. Within this scope, antimicrobial peptides (AMPs), which are small, cationic and amphipathic peptides that comprise a section of the innate immune system, are currently the leading potential agents for the treatment of TB. Many studies have recently illustrated the capability of anti-mycobacterial peptides to disrupt the normal mycobacterial cell wall function through various modes, thereby interacting with the intracellular targets, as well as encompassing nucleic acids, enzymes and organelles. This review presents a wide array of antimicrobial activities, alongside the associated properties of the AMPs that could be utilized as potential agents in therapeutic tactics for TB treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2017.10.011