Stem cell-based therapy: Improving myocardial cell delivery

• Published in: Advanced drug delivery reviews Vol. 106; no. Pt A; pp. 104 - 115
• Main Authors: Feyen, Dries A.M., Gaetani, Roberto, Doevendans, Pieter A., Sluijter, Joost P.G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.11.2016
• Subjects: Animals; Cell retention; Cell therapy; Cell- and Tissue-Based Therapy - methods; Humans; Myoblasts, Cardiac - cytology; Myoblasts, Cardiac - transplantation; Myocardial repair; Progenitor cell; Stem cell; Stem Cell Transplantation - methods; Cell retention; Cell therapy; Myocardial repair; Stem cell; Progenitor cell
• ISSN: 0169-409X; 1872-8294
• DOI: 10.1016/j.addr.2016.04.023

Stem cell-based therapies form an exciting new class of medicine that attempt to provide the body with the building blocks required for the reconstruction of damaged organs. However, delivering cells to the correct location, while preserving their integrity and functional properties, is a complex undertaking. These challenges have led to the development of a highly dynamic interdisciplinary research field, wherein medical, biological, and chemical sciences have collaborated to develop strategies to overcome the physiological barriers imposed on the cellular therapeutics. In this respect, improving the acute retention and subsequent survival of stem cells is key to effectively increase the effect of the therapy, while proper tissue integration is imperative for stem cells to functionally replace lost cells in damaged organs. In this review, we will use the heart as an example to highlight the current knowledge of therapeutic stem cell utilization, the existing pitfalls and limitations, and the approaches that have been developed to overcome them. [Display omitted]