Response to Letter Regarding Article: "Developing DCE-CT to Quantify Intra-Tumor Heterogeneity in Breast Tumors With Differing Angiogenic Phenotype"

In this response letter, technical issues raised by the comments concerning determination of arterial input function, cardiac and respiratory related motion artifacts, contrast agent application, and compartmental model fitting in our work are addressed in detail, and a discussion on identifying cau...

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Bibliographic Details
Published inIEEE transactions on medical imaging Vol. 29; no. 4; pp. 1089 - 1092
Main Authors Minsong Cao, Yun Liang, Stantz, K.M.
Format Journal Article
LanguageEnglish
Published New York IEEE 01.04.2010
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects
Animals
Biomedical imaging
Breast tumors
Cancer
Compartmental model
Computed tomography
dynamic contrast enhanced computed tomography (DCE-CT)
Immune system
Indexing in process
Measurement uncertainty
Mice
Neoplasms
Plasma measurements
tumor heterogeneity
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Summary:In this response letter, technical issues raised by the comments concerning determination of arterial input function, cardiac and respiratory related motion artifacts, contrast agent application, and compartmental model fitting in our work are addressed in detail, and a discussion on identifying causes of uncertainty in physiological measurement and how to minimize their contribution is presented.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0278-0062
1558-254X
DOI:10.1109/TMI.2009.2039224