Calcium functioned carboxymethylated cotton fabric for hemostatic wound dressing

Massive hemorrhage is a frequent cause of human death in the operating room and other emergency situations. Therefore, effective hemostatic wound dressings are essential to save lives. Here we show that, calcium functioned carboxymethylated cotton fabric (MCF-Ca) conveniently prepared by carboxymeth...

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Bibliographic Details
Published inCellulose (London) Vol. 27; no. 17; pp. 10139 - 10149
Main Authors Wang, Yamei, Zhou, Peiwen, Xiao, Dongdong, Liu, Yujun, Zhong, Yi, Wang, Bijia, Zhang, Linping, Chen, Zhize, Sui, Xiaofeng, Feng, Xueling, Xu, Hong, Mao, Zhiping
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.11.2020
Springer Nature B.V
Subjects
Biocompatibility
Bioorganic Chemistry
Blood cells
Calcium chloride
Calcium ions
Carboxymethylation
Ceramics
Chemistry
Chemistry and Materials Science
Clotting
Composites
Cotton
Cotton fabrics
Glass
Hemorrhage
Hemostatics
Natural Materials
Organic Chemistry
Original Research
Physical Chemistry
Polymer Sciences
Saline solutions
Sustainable Development
Wound healing
Wound dressing
Calcium
Hemostatic material
Fabric
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Summary:Massive hemorrhage is a frequent cause of human death in the operating room and other emergency situations. Therefore, effective hemostatic wound dressings are essential to save lives. Here we show that, calcium functioned carboxymethylated cotton fabric (MCF-Ca) conveniently prepared by carboxymethylation of cotton fabrics followed by treatment with calcium chloride solution could serve as an effective hemostatic wound dressing. The calcium content of MCF-Ca was determined as 18.11 ± 0.44 mg/g, and the calcium ions were released into a saline solution, a process that reached near-equilibrium within about 2 min. The biocompatible MCF-Ca promoted hemostasis via forming complexes with blood cells, and it showed lower blood clotting index as well as shorter blood clotting time comparing with unmodified CF in vitro. In addition, MCF-Ca exhibited better hemostatic efficiency than CF in vivo, resulting in much shorter hemostasis time and less blood loss in rat liver injury model and femoral artery animal model. In conclusion, MCF-Ca shows good potential to be used as wound dressing for patients with uncontrolled or massive hemorrhage.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-020-03479-x