A Guardian Angel Phosphatase for Mainline Carbon Metabolism

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 41; no. 11; pp. 893 - 894
• Main Authors: Beaudoin, Guillaume A., Hanson, Andrew D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2016
• Subjects: Fructosediphosphates - metabolism; Gluconates - metabolism; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) - genetics; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) - metabolism; glycolysis; Glycolysis - drug effects; Humans; Hydrolysis; Lactates - metabolism; Lactates - toxicity; metabolite damage; metabolite repair; phosphatase; Phosphoric Monoester Hydrolases - antagonists & inhibitors; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - metabolism; Pyruvate Kinase - genetics; Pyruvate Kinase - metabolism; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - antagonists & inhibitors; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Secondary Metabolism; side-reaction; Sugar Acids - metabolism; Sugar Acids - toxicity; metabolite damage; metabolite repair; phosphatase; side-reaction; glycolysis
• ISSN: 0968-0004; 1362-4326
• DOI: 10.1016/j.tibs.2016.08.005

It is increasingly clear that many metabolic enzymes mistakenly form minor but toxic side-products that must be eliminated to maintain normal fluxes. Collard et al. show that this is true of two iconic glycolytic enzymes, and that a hitherto somewhat mysterious phosphatase rescues central carbon metabolism from their mistakes.