A Guardian Angel Phosphatase for Mainline Carbon Metabolism

It is increasingly clear that many metabolic enzymes mistakenly form minor but toxic side-products that must be eliminated to maintain normal fluxes. Collard et al. show that this is true of two iconic glycolytic enzymes, and that a hitherto somewhat mysterious phosphatase rescues central carbon met...

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Bibliographic Details
Published inTrends in biochemical sciences (Amsterdam. Regular ed.) Vol. 41; no. 11; pp. 893 - 894
Main Authors Beaudoin, Guillaume A., Hanson, Andrew D.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2016
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Summary:It is increasingly clear that many metabolic enzymes mistakenly form minor but toxic side-products that must be eliminated to maintain normal fluxes. Collard et al. show that this is true of two iconic glycolytic enzymes, and that a hitherto somewhat mysterious phosphatase rescues central carbon metabolism from their mistakes.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2016.08.005