Galactorrhea-amenorrhea: psychological interaction with neuroendocrine function

• Published in: American journal of obstetrics and gynecology Vol. 125; no. 6; p. 859
• Main Authors: Zacur, H A, Chapanis, N P, Lake, C R, Ziegler, M, Tyson, J E
• Format: Journal Article
• Language: English
• Published: United States 15.07.1976
• Subjects: Adult; Amenorrhea - drug therapy; Amenorrhea - etiology; Bromocriptine - pharmacology; Bromocriptine - therapeutic use; Clinical Trials as Topic; Contraceptives, Oral; Dopamine Antagonists; Dopamine beta-Hydroxylase - blood; Female; Galactorrhea - drug therapy; Galactorrhea - etiology; Humans; Lactation Disorders - etiology; Norepinephrine - blood; Pregnancy; Prolactin - metabolism; Psychological Tests; Psychophysiologic Disorders
• DOI: 10.1016/0002-9378(76)90863-2
• ISSN: 0002-9378

Further substantiation of the interaction between psychological disease and the onset of galactorrhea-amenorrhea is presented in women who underwent intensive psychometric and neuroendocrine evaluation prior to the use of the dopamine against 2-Br-alpha-ergocryptine (CB-154). Normalization of a previously distorted psychometric test profile in each woman was accompanied by a profound decline in prolactin and an unexpected alteration in the peripheral concentrations of norepinephrine and dopamine-beta-hydroxylase. Cesation of galactorrhea and resumption of menses were observed in each instance.