Clinically malignant exophytic lesions in the background of oral submucous fibrosis: report of five cases

Oral submucous fibrosis (OSF), a common disease in South Asia, is a chronic disorder, and there is a lack of proper scientific understanding about many aspects of the disease. Carcinogenesis in the background of dense fibrosis is considered the most significant aspect of the disease that needs inves...

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Published inOral surgery, oral medicine, oral pathology and oral radiology Vol. 122; no. 2; pp. 210 - 215
Main Authors Jayasinghe, Liyanaarachchige A.H., Peiris, Prasangi M., Tilakaratne, Wanninayake M., Attygalla, Ajith M., Jayasinghe, Ruwan D., Sitheeque, Mohaideen A.M., Siriwardena, Bogahawatte S.M.S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2016
Subjects
Adult
Aged
Areca
Carcinoma, Squamous Cell - pathology
Cell Transformation, Neoplastic - pathology
Humans
Male
Mouth Neoplasms - pathology
Oral Submucous Fibrosis - pathology
Precancerous Conditions - pathology
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Summary:Oral submucous fibrosis (OSF), a common disease in South Asia, is a chronic disorder, and there is a lack of proper scientific understanding about many aspects of the disease. Carcinogenesis in the background of dense fibrosis is considered the most significant aspect of the disease that needs investigation, as the transformation rate is also remarkable compared with other oral potentially malignant disorders. Verrucous growths are a common finding in patients with OSF. We highlight a group of patients who presented with clinically malignant verrucous growths. However, despite the highly suspicious clinical appearance, there was no histologic evidence of invasion. This subgroup of patients with OSF and the inability of the lesion to invade the underlying corium need to be investigated.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2016.06.001