Polyethylene glycol and chitosan functionalized manganese oxide nanoparticles for antimicrobial and anticancer activities

• Published in: Journal of colloid and interface science Vol. 648; pp. 907 - 915
• Main Authors: Mahmood, Arslan, Munir, Tariq, Rasul, Azhar, Ghfar, Ayman A., Mumtaz, Sohail
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2023
• Subjects: Anti-Infective Agents - pharmacology; Anticancer; Antimicrobial; Chitosan - pharmacology; Humans; Nanoparticles - chemistry; Oxides - chemistry; Oxides - pharmacology; Polyethylene Glycols - chemistry; Polymers; Remote control; Surface functionalized Mn3O4-NPs; Surface functionalized Mn3O4-NPs; Antimicrobial; Anticancer; Remote control; Surface functionalized MnO-NPs
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2023.06.029

[Display omitted] Biocompatible polymer-functionalized magnetic nanoparticles could offer promising applications in biomedical sciences. We fabricated polymer functionalized tri-manganese tetra oxide (Mn3O4) nanoparticles with the co-precipitation method and an octahedral crystal structure having a crystallite size of 10–17 nm was identified via XRD analyses. The SEM graph depicted the non-uniform and smooth surface of PEG-functionalized Mn3O4 NPs as compared to Mn3O4 and chitosan-coated Mn3O4 NPs. Elemental composition in the prepared sample was examined by EDX analysis. Various modes such as MnO, MnOH, OH, symmetric, and anti-symmetric of CH2 attached to the spectrum of Mn3O4 NPs were observed with FTIR analysis. The magnetization factor decreased and increase the coreacivity and retentivity of surface functionalized Mn3O4-NPs was calculated via VSM analysis. In-vitro bioassay, antibacterial activity was tested against Escherichiacoli, Bacillus cereus, and anti-fungal activities against two Fusarium strains indicated clear antimicrobial activities. The MTT assay to examine the anticancer activity against the MCF-7 cancer cell line was performed and the T1 MRI contrast agent demonstrated that PEG-coated Mn3O4 NPs exhibited anti-cancer activities. We propose that surface-functionalized magnetic NPs used for the treatment of cancer by using a remote controlled process of hyperthermia therapy.