MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males

• Published in: Oncotarget Vol. 8; no. 15; pp. 25177 - 25188
• Main Authors: Chen, Junyu, Liu, Wanlin, Cao, Yuju, Zhang, Xiyang, Guo, Yongchang, Zhu, Yong, Li, Jian, Du, Jieli, Jin, Tianbo, Wang, Guoqiang, Wang, Jianzhong
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 11.04.2017
• Subjects: Adult; Alcohol Drinking - adverse effects; Alleles; Asian Continental Ancestry Group; Case-Control Studies; China; Femur Head Necrosis - epidemiology; Femur Head Necrosis - etiology; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 8 - genetics; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Research Paper; genetic; MMP-8; alcohol-induced osteonecrosis of the femoral head; single-nucleotide polymorphism; MMP-3
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.15587

Our study investigated the association between MMP-3 and MMP-8 single-nucleotide polymorphisms (SNPs) and alcohol-induced osteonecrosis of the femoral head (ONFH) in 695 Chinese males (299 cases and 396 control subjects). The minor allele of MMP-3 rs650108 was associated with a 0.78-fold decrease in alcohol-induced ONFH risk in the allelic model (95% CI = 0.63-0.97, P = 0.026). In the genetic model adjusted for age, rs650108 was associated with decreased risk of alcohol-induced ONFH in the dominant model (OR = 0.68, 95% CI = 0.49-0.95, P = 0.022) and log-additive model (OR = 0.78, 95% CI = 0.63-0.98, P = 0.030); MMP-8 rs11225394 was associated with increased risk in the codominant model (OR = 1.72, 95% CI = 1.15-2.58, P= 0.010), dominant model (OR = 1.67, 95% CI = 1.12-2.48, P = 0.012), over-dominant model (OR = 1.73, 95% CI = 1.16-2.59, P = 0.007) and log-additive model (OR = 1.57, 95% CI= 1.07-2.32, P = 0.022); and MMP-8 rs2012390 was associated with decreased risk in the dominant model (OR = 0.72, 95% CI = 0.53-0.97, P = 0.032) and log-additive model (OR = 0.77, 95% CI = 0.60-0.98, P = 0.035). Haplotype analysis showed that the CGATATGT sequence mediated decreased alcohol-induced ONFH risk (OR = 0.75, 95% CI = 0.57-0.97, P = 0.029). Therefore, among Chinese males, MMP-3 rs650108 and MMP-8 rs2012390 decrease alcohol-induced ONFH risk and MMP-8 rs11225394 increases it. Further study is needed to validate our conclusion.