Chemokine receptor CXCR7 is an independent prognostic biomarker in glioblastoma

• Published in: Cancer biomarkers : section A of Disease markers Vol. 20; no. 1; pp. 1 - 6
• Main Authors: Deng, Lina, Zheng, Wenxin, Dong, Xueshuang, Liu, Jianghua, Zhu, Chunyu, Lu, Dan, Zhang, Jin, Song, Laijun, Wang, Yuchao, Deng, Dan
• Format: Journal Article
• Language: English
• Published: Netherlands IOS Press BV 19.07.2017
• Subjects: Adolescent; Adult; Adults; Aged; Biomarkers; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Brain; Brain cancer; Brain Neoplasms - genetics; Brain Neoplasms - metabolism; Cancer; Chemokines; Chemotherapy; DNA Methylation; Female; Genetics; Glioblastoma; Glioblastoma - genetics; Glioblastoma - metabolism; Humans; Immunohistochemistry; Male; Medical prognosis; Methylation; Middle Aged; Multivariate Analysis; Pathogenesis; Prognosis; Radiation therapy; Receptors, CXCR - biosynthesis; Receptors, CXCR - genetics; Subgroups; Surgery; Survival; Survival Analysis; Tumors; Young Adult; prognostic biomarker; CXCR7; Glioblastoma; survival
• ISSN: 1574-0153; 1875-8592
• DOI: 10.3233/CBM-151430

Glioblastoma (GBM) is the most common and most fatal primary brain cancer in adults. Due to the complex nature of GBM, its pathogenesis still remain unclear. Accumulating evidence suggest that chemokine receptor CXCR7 contribute to the development of various types of tumors. We aim to examine the prognostic significance of CXCR7 in GBM. CXCR7 were first detected by Immunohistochemistry. The association between CXCR7 and overall survival (OS) were examined. Moreover, multivariate analyses were conducted to evaluate the prognostic factors in GBM. Of all 146 GBM patients recruited, 77 were in the high-expression subgroup, the rest 69 were in low-expression subgroup. There are no differences between these two subgroups in terms of age, gender, family history of cancer, extent of surgery, chemotherapy, radiotherapy, KPS, MGMT methylation status and tumor size. However, high CXCR7 expression was robustly correlated with poor OS in GBM. Multivariate analysis confirmed age, KPS scores, chemotherapy, IDH1 mutation, MGMT methylation and CXCR7 were independent factors in survival prognosis. CXCR7 may involve in the clinical GBM progression, and CXCR7 could be a valuable prognostic marker in the treatment of GBM.