Anatomic Features of the Interthalamic Adhesion in the Pediatric Population

• Published in: World neurosurgery Vol. 180; pp. e631 - e643
• Main Authors: Kılınç, Mustafa Cemil, Alpergin, Baran Can, Mete, Emre Bahir, Eroglu, Umit, Beger, Orhan
• Format: Journal Article
• Language: English
• Published: United States 01.12.2023
• Subjects: Adolescent; Child; Child, Preschool; Female; Healthy Volunteers; Humans; Infant; Magnetic Resonance Imaging - methods; Male; Retrospective Studies; Thalamus - diagnostic imaging; Third Ventricle; Massa intermedia; Children; Interthalamic adhesion; Magnetic resonance images
• ISSN: 1878-8750; 1878-8769; 1878-8769
• DOI: 10.1016/j.wneu.2023.10.002

The main goal of this retrospective study was to examine the morphology of the interthalamic adhesion (ITA) in normal children aged between 1 and 18 years. The study universe consisted of magnetic resonance images of 180 healthy pediatric subjects (age, 9.50 ± 5.20 years, sex, 90 girls and 90 boys). The cross-sectional area (CSA), vertical diameter (VD), and horizontal diameter (HD) of the ITA were measured and in addition, its location was noted. HD, VD, and CSA of the ITA were measured as 8.47 ± 1.64 mm, 7.59 ± 1.57 mm, and 52.06 ± 18.51 mm , respectively. HD did not change from infancy until postpubescence, but then significantly decreased (P < 0.001). VD increased up to early childhood but then did not alter until the end of prepubescence. After that period, it decreased in postpubescence (P < 0.001). CSA tended to decrease in an irregular pattern according to pediatric age periods (P < 0.001). The ITA was located at the anterosuperior quadrant in 138 individuals (76.70%), at the anteroinferior quadrant in 7 individuals (3.90%), and the center of the lateral wall of the third ventricle in 35 individuals (19.40%). Linear functions were calculated as y = 9.490-0.107 × age (years) for HD, y = 8.453-0.091 × age (years) for VD, and y = 63.559-1.211 × age (years) for CSA. ITA size irregularly decreases with advancing age from 1 to 18 years. Our calculated linear functions, showing the growth dynamics of the ITA by pediatric ages, may be helpful in estimating its dimension.