Avascular necrosis of bone in childhood cancer patients: a possible role of genetic susceptibility

• Published in: Bratislavské lékarské listy Vol. 116; no. 5; pp. 289 - 295
• Main Authors: Geczova, L, Soltysova, A, Gecz, J, Sufliarska, S, Horakova, J, Mladosievicova, B
• Format: Journal Article
• Language: English
• Published: Slovakia 2015
• Subjects: Adrenal Cortex Hormones - adverse effects; Antineoplastic Agents - adverse effects; Catalase - genetics; Child; Genetic Predisposition to Disease; Graft vs Host Disease - complications; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Neoplasms - complications; Neoplasms - therapy; Nitric Oxide Synthase - genetics; Osteonecrosis - etiology; Osteonecrosis - genetics; Plasminogen Activator Inhibitor 1 - genetics; Radiotherapy - adverse effects; Risk Factors; Vascular Endothelial Growth Factor A - genetics; anticancer treatment; osteonecrosis; corticosteroids; avascular necrosis; genetic determinants; transplantation
• ISSN: 0006-9248
• DOI: 10.4149/BLL_2015_055

With the increasing number of paediatric cancer patients and with their prolonged survival, the evidence of a number of serious complications induced by anticancer therapy is rising. Osteonecrosis (ON) of bone is one of these treatment-related effects with a multifactorial pathogenesis. In the past few years, several polymorphisms of candidate genes with possible role in development of this disorder were studied.We summarized potential risk factors leading to increased susceptibility to osteonecrosis of bone development in cancer patients during childhood and to present current knowledge in the field of genetic aspects of this condition (Ref. 86).