Secretome and immune cell attraction analysis of head and neck cancers

• Published in: Cancer Immunology, Immunotherapy : CII Vol. 73; no. 11; p. 229
• Main Authors: Muijlwijk, Tara, Wondergem, Niels E., Ekhlas, Fatima, Remkes, Naomi, Nijenhuis, Dennis N. L. M., Fritz, Lennart, Ganzevles, Sonja H., Miedema, Iris H. C., Leemans, C. René, Poell, Jos B., Brakenhoff, Ruud H., van de Ven, Rieneke
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 09.09.2024; Springer Nature B.V
• Subjects: Antitumor activity; Cancer Research; Cancer-Associated Fibroblasts - immunology; Cancer-Associated Fibroblasts - metabolism; Cell adhesion & migration; Cell migration; Cell Movement; Chemokines; Chemokines - metabolism; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Fibroblasts; Head & neck cancer; Head and neck carcinoma; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Humans; Immune checkpoint inhibitors; Immunity; Immunity (Disease); Immunology; Lymphocytes T; Medicine; Medicine & Public Health; Metastases; Oncology; PD-1 protein; Secretome; Secretome - metabolism; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - immunology; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - pathology; Tumor microenvironment; Tumor Microenvironment - immunology; Tumors; Cancer-associated fibroblasts; Head and neck squamous cell carcinoma; Tumor secretome; Dendritic cells; Chemokines; Immune cell attraction

Immune checkpoint inhibitors are approved for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) but the response rate is only 13–18%. For an effective antitumor immune response, trafficking of immune cells to the tumor microenvironment (TME) is essential. We aimed to better understa...