Tailoring the physicochemical properties of nanomaterials for immunomodulation

Nanomaterial physicochemical properties affect their immunomodulation. Here, size, surface charge, shape, rigidity and surface chemical composition of nanomaterials are discussed for understanding nanomaterials-induced immune responses. [Display omitted] Immunomodulation is poised to revolutionize t...

Full description

Saved in:
Bibliographic Details
Published inAdvanced drug delivery reviews Vol. 180; p. 114039
Main Authors Deng, Junjie, Wang, Jilong, Shi, Jiaqi, Li, Hongjun, Lu, Mingqin, Fan, Zhiyuan, Gu, Zhen, Cheng, Hao
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2022
Subjects
Complement
Drug delivery
Drug Delivery Systems
Humans
Immunoengineering
Immunologic Factors - chemistry
Immunotherapy
Nanomaterials
Nanoparticles - chemistry
Nanomaterials
Complement
Drug delivery
Immunotherapy
Immunoengineering
Online AccessGet full text

Cover

More Information
Summary:Nanomaterial physicochemical properties affect their immunomodulation. Here, size, surface charge, shape, rigidity and surface chemical composition of nanomaterials are discussed for understanding nanomaterials-induced immune responses. [Display omitted] Immunomodulation is poised to revolutionize the treatment of cancer, autoimmune diseases, and many other inflammation-related disorders. The immune system in these conditions can be either activated or suppressed by nanocarriers loaded with bioactive molecules. Although immunomodulation via these therapeutics has long been recognized, and a broad range of nanocarriers have been designed to accommodate varied usages, less studies have focused on the effects of nanomaterial physicochemical properties on immune responses, especially the immunity altered by nanocarrier materials alone. Conclusions are sometimes seemly inconsistent due to the complexities of nanomaterials and the immune system. An in-depth understanding of the nanocarrier-induced immune responses is essential for clinical applications. In this review, we summarize recent studies of the immune responses influenced by nanomaterial physicochemical properties with an emphasis on the intrinsic features of nanomaterials that modulate the innate and adaptive immunities. We then provide our perspectives on the design of nanomaterials for immunomodulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2021.114039