Plaque Reduction, a Sensitive Test for Eastern Encephalitis Antibody

Serologic surveys of vertebrates to determine rates of eastern encephalitis infection were made to discover the most likely disseminators of virus in nature. Of the techniques available, neutralization is the most specific, and antibody is known to persist for many years. This communication reports...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 133; no. 3453; pp. 640 - 641
Main Authors Daniels, Joan B., Ratner, Joan J., Brown, Sylvia R.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 03.03.1961
Subjects
Animals
Antibodies
Antibodies, Viral
Blood
Cultural groups
Encephalitis
Encephalitis - immunology
Humans
Immunoglobulins
Infections
Inoculation
Inoculum
Neutralization Tests
Old Medline
Viremia
Viruses
ENCEPHALITIS/immunology
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Summary:Serologic surveys of vertebrates to determine rates of eastern encephalitis infection were made to discover the most likely disseminators of virus in nature. Of the techniques available, neutralization is the most specific, and antibody is known to persist for many years. This communication reports a fivefold increase in sensitivity of neutralizing-antibody detection by the application of a plaque-reducing technique.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.133.3453.640