Reovirus Hemagglutination: Inhibition by N-Acetyl-D-glucosamine

Purified reoviruses types 1, 2, and 3 were specifically inhibited in their hemagglutination of human erythrocytes by 250 micromoles or more of N-acetyl-D-glucosamine but not by over 20 other sugars tested. N-acetyl-D-glucosamine inhibited reovirus hemagglutination by binding to capsid virus; it did...

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Published inScience (American Association for the Advancement of Science) Vol. 147; no. 3656; pp. 404 - 405
Main Authors Gelb, Lawrence D., Lerner, A. Martin
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 22.01.1965
Subjects
Acetylglucosamine
Blood groups
Carbohydrates
Embryos
Erythrocytes
Glucosamine
Hemagglutination
Hexosamines
Humans
Messenger RNA
Old Medline
Pharmacology
Polyribosomes
Reoviridae
Ribosomes
Sugars
Vertebrates
Viruses
PHARMACOLOGY
VERTEBRATE VIRUSES
EXPERIMENTAL LAB STUDY
HEMAGGLUTINATION
REOVIRUS
CARBOHYDRATES
HEXOSAMINES
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Summary:Purified reoviruses types 1, 2, and 3 were specifically inhibited in their hemagglutination of human erythrocytes by 250 micromoles or more of N-acetyl-D-glucosamine but not by over 20 other sugars tested. N-acetyl-D-glucosamine inhibited reovirus hemagglutination by binding to capsid virus; it did not attach to the erythrocytes. It is possible that reovirus hemagglutination involves union between N-acetyl-D-glucosamine on the surface of the red cell and the glycoprotein of the virus coat.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.147.3656.404