Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation
► NK cells are differentiated from hematopoietic stem cells. ► Tanshinones induce NK cell differentiation. ► Tanshinones activates p38 pathway. Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinon...
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Published in | Biochemical and biophysical research communications Vol. 425; no. 2; pp. 340 - 347 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
24.08.2012
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Subjects | |
Online Access | Get full text |
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Summary: | ► NK cells are differentiated from hematopoietic stem cells. ► Tanshinones induce NK cell differentiation. ► Tanshinones activates p38 pathway.
Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones significantly increased IL-15-induced NK cell differentiation via enhancing the p38 phosphorylation and the expression of transcription factors. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1016/j.bbrc.2012.07.093 |