Effect of borneol, moschus, storax, and acorus tatarinowii on expression levels of four amino acid neurotransmitters in the rat corpus striatum

• Published in: Neural regeneration research Vol. 7; no. 6; pp. 440 - 444
• Main Authors: Zhang, Na, Liu, Ping, He, Xinrong
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt. Ltd 25.02.2012; Pharmacy of Traditional Chinese Medicine, Drugs Supply Centre of PLA General Hospital, Beijing 100853, China; Department of Pharmacy, Shijiazhuang Fourth Hospital, Shijiazhuang 050011, Hebei Province, China%Pharmacy of Traditional Chinese Medicine, Drugs Supply Centre of PLA General Hospital, Beijing 100853, China; Medknow Publications & Media Pvt Ltd
• Subjects: Amino acids; Anesthesia; Chromatography; Convulsions & seizures; Drug dosages; Influence; Laboratory animals; Nervous system; Neurotransmitters; Permeability; Pharmaceuticals; Pharmacy; Physiology; Research and Report: Traditional Chinese Medicine and Neuroregeneration; Traditional Chinese medicine; 兴奋性神经递质; 冰片; 反相高效液相色谱法; 大鼠; 抑制性神经递质; 氨基酸类神经递质; 石菖蒲; 麝香; Beijing China; China; acorus tatarinowii; moschus; resuscitation drugs; microdialysis; amino acid; high-performance liquid chromatography; neurotransmitter; borneol; storax
• ISSN: 1673-5374; 1876-7958
• DOI: 10.3969/j.issn.1673-5374.2012.06.006

The present study collected cerebrospinal fluid samples from the corpus striatum in rats treated with borneol, moschus, storax, and acorus tatarinowii using brain microdialysis technology. Levels of excitatory neurotransmitters aspartic acid and glutamate, as well as inhibitory neurotransmitters glycine and ~-aminobutyric acid, were measured in samples using reversed-phase high-performance liquid chromatography, phosphate gradient elution, and fluorescence detection. Results showed that concentrations of all four amino acid neurotransmitters significantly increased in the corpus striatum following treatment with borneol or moschus, but effects due to borneol were more significant than moschus. Acorus tatarinowii treatment increased ~-aminobutyric acid expression, but decreased glutamate concentrations. Storax increased aspartic acid concentrations and decreased glycine expression. Results demonstrated that borneol and moschus exhibited significant effects on con amino acid neurotransmitter expression; storax exhibited excitatory effects and acorus tatarinowii resulted in inhibitory effects.