Intravascular large T-cell lymphoma : a case report of CD30-positive and ALK-negative anaplastic type with cytotoxic molecule expression

• Published in: Virchows Archiv : an international journal of pathology Vol. 447; no. 6; pp. 1000 - 1006
• Main Authors: TAKAHASHI, Emiko, KAJIMOTO, Kazuyoshi, FUKATSU, Toshiaki, YOSHIDA, Megumi, EIMOTO, Tadaaki, NAKAMURA, Shigeo
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.12.2005; Springer Nature B.V
• Subjects: Aged; Alkaline Phosphatase - metabolism; Antigens, CD - metabolism; Biological and medical sciences; Biomarkers, Tumor - analysis; Cancer; Cell morphology; Cells; Hematologic and hematopoietic diseases; Herpesvirus 4, Human - isolation & purification; Humans; Immunohistochemistry; In Situ Hybridization; Investigative techniques, diagnostic techniques (general aspects); Ki-1 Antigen - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma; Lymphoma, Large B-Cell, Diffuse - metabolism; Lymphoma, Large B-Cell, Diffuse - pathology; Lymphoma, T-Cell - metabolism; Lymphoma, T-Cell - pathology; Male; Medical sciences; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Immunohistochemistry; Intravascular lymphoma; Anaplastic large cell morphology; Cytotoxicity; Malignant hemopathy; Large cell lymphoma; Histiocytosis; Non Hodgkin lymphoma; Case study; Hemophagocytic syndrome; Anatomic pathology; Cytotoxic T cell; Lymphoproliferative syndrome; Morphology; Cell; Cytotoxic T lymphocyte
• ISSN: 0945-6317; 1432-2307
• DOI: 10.1007/s00428-005-0080-6

We reported a case of intravascular T-cell lymphoma (T-IVL) with anaplastic large cell morphology, the hemophagocytic syndrome, and an aggressive clinical course. Phenotypic analysis of the tumor cells revealed CD2+, CD3-, CD4+, CD5-, CD8-, CD30+, CD56-, T-cell receptor alpha/beta-, ALK-, TIA1+, granzyme B+, and perforin+. No association with Epstein-Barr virus was found by in situ hybridization. A review revealed that 25 cases of T-IVL have been reported in the available literature, only two of which were of CD30+ anaplastic large cell or cytotoxic T-cell type. The findings in the present case may highlight the unique clinicopathologic aspects of a subset of CD30-positive T-IVLs with an ALK-negative cytotoxic phenotype.