Metabolite features and oxidative response in kidney of red crucian carp (Carassius auratus red var) after Aeromonas hydrophila challenge

• Published in: Comparative biochemistry and physiology. Toxicology & pharmacology Vol. 255; p. 109293
• Main Authors: Xiong, Ning-Xia, Mao, Zhuang-Wen, Ou, Jie, Fan, Lan-Fen, Chen, Yuan, Luo, Sheng-Wei, Luo, Kai-Kun, Wen, Ming, Wang, Shi, Hu, Fang-Zhou, Liu, Shao-Jun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2022
• Subjects: Aeromonas hydrophila; Animals; Crucian carp; Fish Diseases - microbiology; Gene Expression Regulation; Goldfish; Gram-Negative Bacterial Infections - microbiology; Gram-Negative Bacterial Infections - veterinary; Kidney - pathology; Metabolomics; Oxidative stress; Reactive Oxygen Species; Crucian carp; Aeromonas hydrophila; Metabolomics; Oxidative stress
• ISSN: 1532-0456; 1878-1659
• DOI: 10.1016/j.cbpc.2022.109293

Aeromonas hydrophila can threaten the survival of freshwater fish. In this study, A. hydrophila challenge could induce tissue damage, promote antioxidant imbalance as well as alter the transcript levels of oxidative stress indicators, apoptotic genes and metabolic enzyme genes in kidney of red crucian carp (RCC). Metabolomics analysis revealed that A. hydrophila challenge had a profound effect on amino acid metabolism and lipid metabolism. In addition, we further identified dipeptides, fatty acid derivatives, cortisol, choline and tetrahydrocortisone as crucial biomarkers in kidney of RCC subjected to A. hydrophila infection. These results highlighted the importance of metabolic strategy against bacterial infection. [Display omitted] •Acute A. hydrophila infection could induce tissue damage in kidney of RCC.•Decreased level of antioxidant status was observed in kidney of RCC following A. hydrophila challenge.•hydrophila infection could decrease levels of dipeptides and fatty acid derivatives in kidney of RCC.