Targets for endothelin in the diseased kidney: clues for therapeutic intervention

The endothelin system has been implicated in various renal diseases. This review focuses on the involvement of endothelin-1 in pathogenesis and pathophysiology of acute and chronic renal failure with regard to its hemodynamic and nonhemodynamic effects. Future developments concerning the use of endo...

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Bibliographic Details
Published inExperimental nephrology Vol. 7; no. 1; p. 1
Main Authors Rohmeiss, P, Birck, R, Braun, C, Kirchengast, M, van der Woude, F J
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1999
Subjects
Acute Kidney Injury - etiology
Acute Kidney Injury - physiopathology
Animals
Clinical Trials as Topic
Endothelin Receptor Antagonists
Endothelin-1 - physiology
Humans
Kidney Diseases - drug therapy
Kidney Diseases - etiology
Kidney Diseases - physiopathology
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - physiopathology
Kidney Transplantation
Models, Biological
Renal Circulation - physiology
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Summary:The endothelin system has been implicated in various renal diseases. This review focuses on the involvement of endothelin-1 in pathogenesis and pathophysiology of acute and chronic renal failure with regard to its hemodynamic and nonhemodynamic effects. Future developments concerning the use of endothelin receptor antagonists and the role of endothelin in the kidney transplantation setting are discussed.
ISSN:1018-7782
DOI:10.1159/000020577