The Use of 20% Subcutaneous Immunoglobulin Replacement Therapy in Patients With B Cell Non-Hodgkin Lymphoma With Humoral Immune Dysfunction After Treatment With Rituximab

• Published in: Clinical lymphoma, myeloma and leukemia Vol. 20; no. 9; pp. e590 - e596
• Main Authors: Mustafa, S. Shahzad, Jamshed, Saad, Vadamalai, Karthik, Ramsey, Allison
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2020
• Subjects: Non-Hodgkin lymphoma; Secondary immunodeficiency; Subcutaneous immunoglobulin; Vaccine responses; Non-Hodgkin lymphoma; Subcutaneous immunoglobulin; Vaccine responses; Secondary immunodeficiency
• ISSN: 2152-2650; 2152-2669
• DOI: 10.1016/j.clml.2020.04.006

Rituximab is an anti-CD20 chimeric antibody used to treat autoimmune conditions and B cell neoplasms. We characterized immunoglobulin (Ig) levels and vaccine responses in rituximab-treated B cell non-Hodgkin lymphoma (NHL) patients. Patients with impaired vaccine responses were offered therapy with 20% subcutaneous (subq) Ig. Patients with a biopsy-proven diagnosis of B cell NHL who had received rituximab within the past 24 months were eligible for the study and underwent the following immune evaluation: serum IgG, IgM, IgA, IgE, T/B cell lymphocyte panel, and pre/post vaccine IgG titers to diphtheria, tetanus, and streptococcus pneumoniae. Patients were vaccinated with tetanus, diphtheria and pneumococcal polysaccharide vaccine. Patients with abnormal vaccine responses were offered prophylactic subq Ig for 52 weeks. Fifteen patients with NHL were enrolled in the study. The median IgG was 628 mg/dL [interquartile range, 489-718 mg/dL]. Three (20%) of 15 patients responded to diphtheria vaccination, 1 (6.7%) of 15 responded to tetanus vaccination, and 3 (20%) of 15 responded to vaccination to streptococcus pneumoniae. Thirteen (86.7%) of 15 met criteria for humoral immunodeficiency. Ten patients received subq Ig, and experienced a significant increase in serum IgG (P = .008). There were no serious adverse events, and there was a decrease in nonneutropenic infections while on subq Ig therapy. Patients with NHL treated with rituximab may have significant humoral immunodeficiency as defined by abnormal vaccine responses even in the setting of relatively normal IgG levels. For these patients, subq Ig replacement therapy is well-tolerated and efficacious in improving serum IgG, and may decrease reliance on antibiotics for the treatment of nonneutropenic infections. Rituximab can cause impaired vaccine responses despite adequate immunoglobulin G (IgG) levels. Fifteen patients with non-Hodgkin lymphoma were enrolled, with a median IgG of 628 mg/dL (interquartile range, 489-718 mg/dL), yet 13 (86.7%) of 15 patients met criteria for humoral immunodeficiency. Ten patients received subcutaneous Ig, which was well-tolerated and efficacious in improving serum IgG, and decreased reliance on antibiotics for nonneutropenic infections.