Synthesis of some novel dimethine, bis-dimethine cyanine dyes and octacosamethine cyanine dyes endowed with promising biological potency against (HepG2), (Hela), (MCF-7), (MIA), (SN12C) and (H358) cell lines

• Published in: Bioorganic & medicinal chemistry letters Vol. 28; no. 10; pp. 1747 - 1752
• Main Authors: El-Mekawy, Rasha E., Fadda, A.A.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.06.2018; Elsevier
• Subjects: Alkenes - chemical synthesis; Alkenes - chemistry; Alkenes - pharmacology; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Bis-dimethine cyanie dyes; Carbocyanines - chemical synthesis; Carbocyanines - chemistry; Carbocyanines - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Dimethine cyanine dyes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fluorescent Dyes - pharmacology; Humans; Life Sciences & Biomedicine; Liver cancer cell; Molecular Structure; Octacosamethine cyanine dyes; Pharmacology & Pharmacy; Physical Sciences; Porphyrin; Science & Technology; Structure-Activity Relationship; Bis-dimethine cyanie dyes; Liver cancer cell; Porphyrin; Octacosamethine cyanine dyes; Dimethine cyanine dyes; FLUORESCENT; SPECTRAL SENSITIZATION; DYNAMICS
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2018.04.032

Successfully, one step two component synthesis of dimethine cyanine dyes, bis-dimethine cyanine dyes and icosamethine cyanine dyes 2–10via reaction of pyridinium salt 1 with some different aldehydes hoping to obtain these compounds with enhanced biological potency as antitumor agents against spontaneous liver (HepG2), cervical (Hela), breast (MCF-7), pancreas (MIA), kidney (SN12C) and lung (H358). Structure activity relationship (SAR) reflects the effect of substituted drugs. Among these dyes, icosamethine cyanine dye 8 recorged excellent activity toward all the tested cell lines. [Display omitted] •Synthesis of methane cyanine dyes.•Confirmed by spectral analyses.•Activity as antitumor agents. Successfully, one step two component synthesis of dimethine cyanine dyes, bis-dimethine cyanine dyes and icosamethine cyanine dyes 2–10via reaction of pyridinium salt 1 with some different aldehydes hope to obtain these compounds with enhanced biological potency as antitumor agents against spontaneous liver (HepG2), cervical (Hela), breast (MCF-7), pancreas (MIA), kidney (SN12C) and lung (H358). The impact of substituted drugs on the tumor cells was reflected by means of structure activity relationship (SAR). Among these dyes, icosamethine cyanine dye 8 recorded an excellent activity toward all the tested cell lines. The newly destined drugs were identified and emphasized by spectroscopy and elemental analyses.