Determination of Acetaminophen in the Presence of Ascorbic Acid Using a Glassy Carbon Electrode Modified with Poly(Caffeic acid)

• Published in: International journal of electrochemical science Vol. 9; no. 1; pp. 148 - 160
• Main Authors: Filik, Hayati, Avan, Asiye Aslihan, Aydar, Sevda, Çetintaç, Gamze
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2014
• Subjects: Acetaminophen; Paracetamol; Pharmaceutical Analysis; Poly(caffeic acid); Voltammetry; Voltammetry; Paracetamol; Pharmaceutical Analysis; Acetaminophen; Poly(caffeic acid)
• ISSN: 1452-3981; 1452-3981
• DOI: 10.1016/S1452-3981(23)07704-0

A stable electroactive thin film of poly(caffeic acid) was deposited on the surface of a glassy carbon electrode by potentiostatic technique in an aqueous solution containing caffeic acid. The electrochemical behaviors of acetaminophen on poly(caffeic acid) modified glassy carbon electrodes (poly(CA)-GCEs) were investigated by cyclic voltammetry and square-wave voltammetry (SWV). The results obtained that the poly(CA)-modified electrode was exhibited excellent electrochemical activity on the oxidation of acetaminophen. The calibration curve for APAP was shown two linear segments: the first linear segment increases from 0.2 to 1.0 and second linear segment increases up to 10 μM. Using the first range of this calibration plot, a detection limit of 0.026 μM is obtained for acetaminophen using square wave voltammetry. The poly(CA) electrode is selective not only for the detection of acetaminophen in the presence of ascorbic acid, dopamine, p-aminophenol and uric acid but also selective for the simultaneous determination of these four species present in a mixture. Finally, the proposed method was successfully applied to analysis of acetaminophen in pharmaceutical tablets.