Treadmill and wheel exercise protect against JNK/NF-κB induced inflammation in experimental models of knee osteoarthritis

• Published in: Biochemical and biophysical research communications Vol. 523; no. 1; pp. 117 - 122
• Main Authors: Chen, Liang, Lou, Yiting, Pan, Zheqiang, Cao, Xia, Zhang, Leyong, Zhu, Chang, Liang, Jinxi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.02.2020
• Subjects: JNK/NF-κB; Knee osteoarthritis; Treadmill; Wheel exercise; Wheel exercise; Knee osteoarthritis; JNK/NF-κB; Treadmill
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2019.12.014

Osteoarthritis (OA) remains a challenge for clinicians and effective treatments are lacking. In this study, we investigated JNK/NF-κB signaling in knee OA patients. Rats were used to establish an OA model and were divided into six groups; (1) Control (sterile saline injection only); (2) Controls with treadmill exercise (treadmill); (3) Controls with wheel exercise (wheel); (4) OA (MIA injection); (5) OA with treadmill exercise (OA + treadmill); and (6) OA with wheel exercise (OA + wheel). The results showed that, compared to the OA group, the OA + treadmill and OA + wheel groups had lower levels of IL-1β, IL-6 and TNF-α, and similar levels of p-P65, p-JNK, and P-IκBα. Furthermore, treatment with the JNK agonist anisomycin enhanced the damage to the joint cartilage and increased the levels of IL-1β, IL-6 and TNF-α. Taken together, these data suggest that treadmill and wheel exercise protect against inflammation through the regulation of JNK/NF-κB signaling in experimental models of knee OA. •Inflammation could be detected in the knees of OA rats.•Both treadmill exercise and wheel exercise inhibit inflammation in knee OA rats.•Both treadmill exercise and wheel exercise inhibit JNK/NF-κB signaling.