Post-Operative Outcomes of Pre-Thoracic Surgery Respiratory Muscle Training vs Aerobic Exercise Training: A Systematic Review and Network Meta-analysis

• Published in: Archives of physical medicine and rehabilitation Vol. 104; no. 5; pp. 790 - 798
• Main Authors: Kunadharaju, Rajesh, Saradna, Arjun, Ray, Andrew, Yu, Han, Ji, Wenyan, Zafron, Michelle, Mador, Martin Jeffery
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2023
• Subjects: Aerobic exercise; Bayes Theorem; Breathing Exercises; Exercise; Humans; Length of stay; Network Meta-Analysis; Pneumonia; Pneumonia - prevention & control; Postoperative complications; Postoperative Complications - epidemiology; Postoperative Complications - prevention & control; Rehabilitation; Thoracic Surgery; Pneumonia; PPC; NMA; OR; PRF; CI; HLOS; I2; SUCRA; AET; MD; RMT; Breathing exercises; Rehabilitation; Postoperative complications; Aerobic exercise; Length of stay
• ISSN: 0003-9993; 1532-821X
• DOI: 10.1016/j.apmr.2022.10.015

To compare the postoperative outcomes of preoperative respiratory muscle training (RMT) with a device to preoperative aerobic exercise training (AET) in patients undergoing thoracic surgeries (cardiac and lung). PubMed, EMBASE, Cochrane, and Web of Science were comprehensively searched upon inception to 9/2020. All randomized control studies, including preoperative RMT and preoperative AET compared with a non-training control group, were included. The meta-analysis was performed for outcomes including postoperative pulmonary complications (PPC), pneumonia, postoperative respiratory failure (PRF), hospital length of stay (HLOS), and mortality. We performed a network meta-analysis based on Bayesian random-effects regression models. A total of 25 studies, 2070 patients were included in this meta-analysis. Pooled data for the patients who performed RMT with a device showed a reduction in PPCs, pneumonia, PRF with odds ratio (OR) of 0.35 (P value .006), 0.38 (P value .002), and 0.22 (P value .008), respectively. Pooled data for the patients who performed AET showed reduction in PPC, pneumonia with a OR of 0.33 (P value <.00001) and OR of 0.54 (P value .01), respectively. HLOS was decreased by 1.69 days (P value <.00001) by performing RMT and 1.79 days (P value .0008) by performing AET compared with the usual group. No significant difference in all-cause mortality compared with usual care in both RMT and AET intervention groups. No significant difference in the incidence of PRF compared with usual group in RMT + AET and AET alone intervention groups (OR 0.32; P=.21; OR 0.94; P=.87). Based on rank probability plots analysis, on network meta-analysis, RMT and AET ranked similarly on the primary outcome of PPC and secondary outcomes of pneumonia, PRF and HLOS. In thoracic surgeries, preoperative RMT is comparable with preoperative AET to prevent PPC, pneumonia, and PRF and reduce HLOS. It can be considered in patients in resource-limited settings.