Haptoglobin genotype 2-2 associated with atherosclerosis in patients with ischemic stroke

•We studied the effect of Hp genotypes on ischemic stroke and atherosclerosis in males and females.•Presence of hypertension, HDL, CRP, age and male gender increased the risk of stroke.•Genotype Hp2-2 was statistically significantly associated with ischemic stroke.•We can point to the Hp 2–2 genotyp...

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Published inGene Vol. 752; p. 144786
Main Authors Merkler, A., Sertić, J., Bazina Martinović, A., Križ, T., Miličić, I., Šimić, M., Caban, D., Ljubić, H., Markeljević, J., Šimičević, L., Kaštelan, S., Pećin, I., Reiner, Ž.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 20.08.2020
Subjects
Carotid atherosclerotic lesions
Hp2-2 genotype
Stroke
CRP
Carotid atherosclerotic lesions
Stroke
Hp
IS
Hb
CDFI
PCR
Hp2-2 genotype
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Summary:•We studied the effect of Hp genotypes on ischemic stroke and atherosclerosis in males and females.•Presence of hypertension, HDL, CRP, age and male gender increased the risk of stroke.•Genotype Hp2-2 was statistically significantly associated with ischemic stroke.•We can point to the Hp 2–2 genotype as genetic risk factor for prediction of atherosclerosis in patients with IS. Ischemic stroke (IS) is multifactorial disease and therefore different genes and proteins play a role in its development. Haptoglobin (Hp) removes free hemoglobin and protects from iron-induced oxidative damage, inflammatory response, atherosclerosis and cerebrovascular diseases. The aim of this study was to investigate Hp genetic variants in patients with carotid atherosclerotic lesions and IS. A total of 121 subjects with IS participated in the study, 81 male and 40 female. Among 121 patients with IS, 79 had diffuse atherosclerotic plaques and stenosis. Hp genotype was statistically significantly associated with CDFI neck carotid artery stenosis findings (p = 0.006). Patients with Hp1-2 genotype had statistically significantly larger odds for atherosclerotic changes compared to those with Hp1-1 genotype, as well as those with Hp2-2 genotype. This study has shown an association of the Hp2-2 genotype and atherosclerosis in patients with IS, indicating Hp2-2 genotype as a genetic biomarker for precision medicine and personalized healthcare.
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ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2020.144786